Basic Information:
Product Name: trans-4-Dimethylaminocrotonic acid hydrochloride
Synonyms: (2E)-4-(Dimethylamino)-2-butenoic acid hydrochloride; Afatinib int-2 Trans-4-Dimethylaminocrotonic acid hydrochloride; 2-Butenoic acid, 4-(dimethylamino)-, (2E)-, hydrochloride; trans-4-Dimethylaminocrotonic acid hydrochloride, >=97%; trans-4-Dimethylaminocrotonic; trans-4-dimethylaminocrotonic acid hydrochloride salt; 2-Butenoic acid,4-(dimethylamino)-, hydrochloride (1:1), (2E)-; trans-4-Dimethylaminocrotonic acid hydrochloride(848133-35-7)

CAS: 848133-35-7
MF: C6H12ClNO2
MW: 165.62
EINECS: 617-631-8

Product Categories: Others chemical reagents; Amines; Intermediates & Fine Chemicals; Pharmaceuticals

Chemical Properties:
Melting point: 162 °C
Storage temp.: Inert atmosphere, Room Temperature
Solubility: DMSO (Slightly), Methanol (Slightly), Water (Slightly)
Form: Solid
Color: White to Off-White

Usage and Synthesis:
Description: trans-4-Dimethylaminocrotonic acid hydrochloride is a very important pharmaceutical intermediate and is an essential part of the structure of the anti-tumour drugs afatinib and neratinib. It is also an important organic synthesis reagent for the preparation of novel pyrazole derivatives and 6-heterocycloalkyl quinazoline derivatives.

Uses: trans 4-Dimethylaminocrotonic acid HCl is a reagent used in the preparation of tyrosine kinase inhibiting antitumor agents.

HS Code: 2922498590

Synthesis: trans-4-Dimethylaminocrotonic acid hydrochloride is synthesised using (E)-4-(dimethylamino)-2-butenoic acid methyl ester as a raw material by adding reagents such as water, sodium hydroxide, methanol, and hydrogen chloride through a chemical reaction.