Product Name: Sinistrin
CAS: 37311-25-4
Purity: 98%
Packing: 25kg/drum
Stock: Within 1000kg
Shelf life: About 2 years
Paraben free, No Colors
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1. Introduction:
Sinistrin (CAS 37311-25-4) is a naturally occurring fructan polysaccharide closely related to inulin, found predominantly in the bulbs of Scilla maritima and related plant species. Structurally, sinistrin consists of a branched backbone of fructose residues interconnected by both β-(2→1) and β-(2→6) glycosidic linkages, and carries a terminal glucose unit. Similar to other inulin-type fructans, sinistrin is not hydrolyzed by human digestive enzymes due to the unique conformation of its glycosidic bonds, and thus exhibits no metabolic activity upon parenteral administration.

The clinical significance of sinistrin emerged in the mid-twentieth century when researchers sought a reliable marker for measuring glomerular filtration rate (GFR). Traditional endogenous markers such as creatinine presented limitations including tubular secretion, extra-renal elimination, and dependence on muscle mass, which introduced variability in renal function assessment. Sinistrin circumvented these issues by offering a direct, accurate reflection of the kidney's filtration capacity. Modern pharmaceutical-grade sinistrin is manufactured through advanced extraction and purification processes, supplied as sterile, pyrogen-free solutions or lyophilized powders with defined molecular weight distributions optimized for diagnostic use.

2. Primary Function:
The primary function of sinistrin lies in its role as an ideal marker for GFR measurement. Upon intravenous administration, the compound rapidly distributes throughout the extracellular fluid compartment, achieving uniform concentration equilibrium within minutes. Its hydrophilic nature and molecular weight of approximately 2,000–4,000 daltons enable free filtration through the glomerular membrane while preventing significant back-diffusion or protein binding.

The defining characteristic that distinguishes sinistrin from other markers is its exclusive elimination pathway. Following glomerular filtration, the compound traverses the entire nephron without undergoing tubular reabsorption, active secretion, or metabolic transformation. This inert behavior ensures that urinary sinistrin excretion directly reflects the volume of plasma filtered at the glomerulus. Consequently, sinistrin clearance – calculated as the ratio of urinary excretion rate to plasma concentration – provides an accurate quantitative measure of GFR independent of tubular function or metabolic variables. The compound's metabolic stability, lack of toxicity, and minimal immunogenicity further support its suitability for repeated clinical use.

3. Applications:
- Diagnostic marker for glomerular filtration rate (GFR) measurement in renal function assessment
- Clinical use in nephrology for kidney function testing
- Pharmaceutical-grade sterile solutions and lyophilized powders for diagnostic applications